Fatigue, brain fog, poor recovery, hormone dysregulation, and accelerated aging are rarely caused by a single deficiency. In functional medicine, we look deeper — often to the level of mitochondrial function and cellular repair capacity.

The NAD+ Mitochondrial Reset IV was designed to support these deeper systems by restoring one of the body’s most critical cellular cofactors: NAD+ (Nicotinamide Adenine Dinucleotide).

This protocol goes beyond a standard NAD+ infusion by supporting the full cascade of mitochondrial energy production, oxidative stress balance, and cellular repair signaling.

The Functional Medicine View: Why Mitochondria Matter

Mitochondria are responsible for producing ATP — the energy currency of the cell. But they do far more than produce energy. Healthy mitochondria regulate:
• Hormone signaling
• Neurotransmitter production
• Immune system regulation
• Detoxification capacity
• Inflammation signaling
• Cellular aging pathways

When mitochondrial function declines, we often see systemic symptoms, even when standard labs look normal.

Common drivers of mitochondrial dysfunction include:
• Chronic stress and cortisol dysregulation
• Autoimmune and inflammatory conditions
• Chronic infections or post-viral syndromes
• Environmental toxin exposure
• Blood sugar instability and insulin resistance
• Sleep disruption and circadian rhythm dysregulation

NAD+: The Central Molecule for Cellular Repair and Energy

NAD+ is required for hundreds of metabolic reactions in the body. It is particularly critical for cellular energy production.

NAD+ is required for:
• Glycolysis
• Krebs cycle function
• Electron transport chain activity
• ATP generation

Without adequate NAD+, cells cannot efficiently convert nutrients into usable energy.

DNA Repair and Longevity Signaling

NAD+ activates enzymes called PARPs and Sirtuins, which are involved in:

• DNA repair
• Cellular stress resistance
• Anti-inflammatory signaling
• Healthy aging pathways
• Mitochondrial biogenesis (making new mitochondria)

These pathways are a major focus of longevity and healthy aging research.

Brain and Nervous System Support

NAD+ supports:
• Neurotransmitter synthesis
• Neuroplasticity
• Cognitive clarity
• Nervous system recovery from stress

This is why many patients notice improvements in mental clarity and resilience after NAD+ therapy.

Why NAD+ Alone Is Not Enough: The Mitochondrial Network

In functional medicine, we recognize that cellular repair requires nutrient synergy, not single-nutrient therapy.

Our protocol includes a Nutrient Push because mitochondrial repair depends on:

B Vitamins

Required for:
• Methylation pathways
• Neurotransmitter production
• Energy metabolism enzyme function

Amino Acids

Support:
• Neurotransmitter balance
• Detoxification pathways
• Cellular repair signaling

Minerals

Required for:
• ATP synthesis
• Mitochondrial enzyme activation
• Nervous system regulation

This combination supports the stages of mitochondrial repair rather than only supplying NAD+.

Clinical Patterns That Often Benefit From Mitochondrial Support:

While this protocol is not disease-specific, mitochondrial dysfunction is commonly seen in patients with:

• Chronic Fatigue and Burnout Patterns

Especially when labs are “normal” but energy is not.

• Cognitive Overload and Brain Fog

Often linked to mitochondrial demand exceeding supply in the brain.

• Hormone Dysregulation

Steroid hormone production requires mitochondrial function — including progesterone, estrogen, and testosterone synthesis.

• Stress and Nervous System Dysregulation

Chronic sympathetic activation increases mitochondrial oxidative stress and NAD+ depletion.

• Post-Illness or Post-Viral Recovery

Mitochondrial repair is often needed after immune system activation or prolonged inflammation.

Optional Advanced Support: Methylene Blue

For appropriate patients, an optional compounded Methylene Blue prescription can be added.

Methylene Blue may support:
• Electron transport chain efficiency
• Cellular oxygen utilization
• Cognitive energy metabolism

Medication cost is separate. Ordering service is included with your IV protocol (done by Tracy)

Why We Often Recommend a Loading Series

Mitochondrial restoration occurs over time, not in a single treatment.

Single Session: $500
Package (5 Sessions): $2,400
Loading doses are encouraged initially to support sustained NAD+ availability during cellular repair.

Comfort and Safety

NAD+ can cause temporary nausea in some individuals.

To support comfort:
• Zofran available if needed
• Infusion rate adjusted individually
• Continuous monitoring during infusion

Protocol Summary

Formula:
NAD+ 750 mg (protocol-based)

• Nutrient Push (amino acids, minerals, B vitamins)
• Zofran available if needed

Our Functional Medicine Philosophy

We focus on supporting the body’s innate repair systems, not just masking symptoms.

Mitochondrial support is foundational for:
• Energy
• Brain health
• Hormone balance
• Resilience to stress
• Healthy aging

Who Is This Designed For?

This protocol may be especially supportive for individuals who:
• Feel persistently depleted despite lifestyle optimization
• Experience brain fog or mental fatigue
• Are navigating high stress or burnout
• Want proactive longevity and cellular health support
• Are recovering from periods of illness or inflammation

Send us a message or call the office to schedule an appointment to see if NAD+ is for you!