• Tracy Shulsinger

Melatonin, Vit C and Covid-19

In an article we reviewed, researchers are currently looking into Melatonin and Vitamin C as a supplement combination that may be very helpful for people with symptoms.

Here is the link to the article if you are looking for a deeper understanding. Or you can watch the video (above) for a summary.

The basic premise is that there is a statistically far lower chance of morbidity in pregnant mothers and younger children than the rest of the population. Looking at a graph of melatonin production throughout the lifespan shows the distribution:

[Source: Grivas TB, Savvidou OD. Melatonin the “light of night” in human biology and adolescent idiopathic scoliosis. Scoliosis. 2007;2:6. Published 2007 Apr 4. doi:10.1186/1748-7161-2-6]

The hypothesis that is being tested is that melatonin, in combination with Vitamin C, may have a protective effect. The mechanisms are described in detail in the paper. There are dosage suggestions listed at the bottom of the article, and we advise you to consult with your medical provider, especially if you have Diabetes (there are special precautions, like only taking melatonin only after 3 pm among others), and particularly if you have heart disease and are taking ACE inhibitors, which are resulting in increased morbidity/mortality in those who contract Covid-19.

The bottom line: If your healthcare provider is not familiar with this information, send him/her a copy of the article and ask for their recommendation. If you are still having trouble getting good advice on supplements and medication interactions, contact our office and we would be happy to talk with you about scheduling a telemedicine appointment with one of our Functional Medicine providers, who can guide your supplement and medication decisions.

We wish you the very best during this time of transition and evolving information about how we best can support our global community. Let us know if we can be of assistance to you.

If you are looking for a high-quality source for supplements, click to be taken to our The Healing Collective supplement portal.

Take good care of yourself during this time. Be well.

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Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? – The Lancet Respiratory Medicine https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext?fbclid=IwAR0_oLtc0-5KXduN0-5w6MMsrUyHfo7xDWThnXJEtcPO5S1xPwnzHi8Pw7U#bib4

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China – Zhang – – Allergy – Wiley Online Library https://onlinelibrary.wiley.com/doi/full/10.1111/all.14238

COVID-19 and the cardiovascular system | Nature Reviews Cardiology https://www.nature.com/articles/s41569-020-0360-5

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China | Critical Care Medicine | JAMA | JAMA Network  https://jamanetwork.com/journals/jama/fullarticle/2761044

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster – The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30154-9/fulltext

COVID-19, Furins & Hypoxia – The Vitamin C Connection – EvolutaMente.it https://www.evolutamente.it/covid-19-furins-cancer-a-tale-of-vitamin-c-hif/

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC | The FASEB Journal https://www.fasebj.org/doi/full/10.1096/fj.201802418R

The Severe Acute Respiratory Syndrome Coronavirus 3a Protein Up-Regulates Expression of Fibrinogen in Lung Epithelial Cells | Journal of Virology https://jvi.asm.org/content/79/15/10083

The Inflammasomes in Cardiovascular Disease – PubMed https://pubmed.ncbi.nlm.nih.gov/30536166-the-inflammasomes-in-cardiovascular-disease/

Coronavirus Age, Sex, Demographics (COVID-19) – Worldometer https://www.worldometers.info/coronavirus/coronavirus-age-sex-demographics/

‘We simply do not understand why’: Coronavirus is sparing children, puzzling experts https://www.nbcnews.com/health/health-news/we-simply-do-not-understand-why-coronavirus-sparing-children-puzzling-n1147951?fbclid=IwAR39_n7AB3bmBc85Ylbh_J-j-_G4l0PHlmwDV1F86BlfE7WJYArBwr7Q3eQ

Frequently Asked Questions and Answers: Coronavirus Disease-2019 (COVID-19) and Children  https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/children-faq.html

Physiological Melatonin Levels in Healthy Older People: A Systematic Review – PubMed https://pubmed.ncbi.nlm.nih.gov/27302542-physiological-melatonin-levels-in-healthy-older-people-a-systematic-review/

Melatonin as a Hypnotic: Pro – PubMed https://pubmed.ncbi.nlm.nih.gov/15649738-melatonin-as-a-hypnotic-pro/

Fall in Nocturnal Serum Melatonin During Prepuberty and Pubescence – PubMed https://pubmed.ncbi.nlm.nih.gov/6141425-fall-in-nocturnal-serum-melatonin-during-prepuberty-and-pubescence/

Melatonin administration to wild‐type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis – Rahim – 2017 – Journal of Pineal Research – Wiley Online Library https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12410

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism | SpringerLink https://link.springer.com/article/10.1007%2Fs00395-015-0526-1

Melatonin protects lung mitochondria from aging | SpringerLink https://link.springer.com/article/10.1007%2Fs11357-011-9267-8

Chronic melatonin treatment reduces the age‐dependent inflammatory process in senescence‐accelerated mice – Rodríguez – 2007 – Journal of Pineal Research – Wiley Online Library https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.2006.00416.x

Same Molecule but Different Expression: Aging and Sepsis Trigger NLRP3 Inflammasome Activation, a Target of Melatonin – PubMed https://pubmed.ncbi.nlm.nih.gov/26681113-same-molecule-but-different-expression-aging-and-sepsis-trigger-nlrp3-inflammasome-activation-a-target-of-melatonin/

Cytokine Storm and Sepsis Disease Pathogenesis – PubMed https://pubmed.ncbi.nlm.nih.gov/28555385-cytokine-storm-and-sepsis-disease-pathogenesis/

Inflammasomes: Pandora’s box for sepsis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294171/

Melatonin Alleviates Acute Lung Injury Through Inhibiting the NLRP3 Inflammasome – PubMed https://pubmed.ncbi.nlm.nih.gov/26888116-melatonin-alleviates-acute-lung-injury-through-inhibiting-the-nlrp3-inflammasome/

Systemic combined melatonin–mitochondria treatment improves acute respiratory distress syndrome in the rat – Sun – 2015 – Journal of Pineal Research – Wiley Online Library https://onlinelibrary.wiley.com/doi/10.1111/jpi.12199

Care for Critically Ill Patients With COVID-19 | Critical Care Medicine | JAMA | JAMA Network https://jamanetwork.com/journals/jama/fullarticle/2762996

Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production | Respiratory Research | Full Text https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-1325-2

Melatonin possesses an anti-influenza potential through its immune modulatory effect – ScienceDirect https://www.sciencedirect.com/science/article/pii/S1756464619302452Novel

Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China | Global Health | JAMA | JAMA Network https://jamanetwork.com/journals/jama/fullarticle/2761659

Mitochondria & The Coronavirus – The Vitamin C Connection (Part 3) – EvolutaMente.it https://www.evolutamente.it/mitochondria-the-coronavirus-the-vitamin-c-connection-part-3/

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension | Cardiovascular Research | Oxford Academic  https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvz312/5644338?redirectedFrom=fulltext

Light Pollution, Circadian Photoreception, and Melatonin in Vertebrates | HTML https://www.mdpi.com/2071-1050/11/22/6400/htm

Beijing hospital confirms nervous system infections by novel coronavirus – Xinhua | English.news.cn http://www.xinhuanet.com/english/2020-03/05/c_138846529.htm

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China – The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

SARS | Frequently Asked Questions | CDC https://www.cdc.gov/sars/about/faq.html

Coronavirus 2019 (COVID-19) | Frequently Asked Questions | CDC https://www.cdc.gov/coronavirus/2019-ncov/faq.html

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